| عنوان فارسی مقاله: | فاکتور تقویت کننده میوسیت MEF)-2) نقش های ضروری را در تغییر شکل سلول T وابسته به عفونت 1-HTLV با تثبیت کمپلکس بین Tax و CREB ایفا میکند |
| عنوان انگلیسی مقاله: | Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB |
چکیده
نتایج
بحث
نتیجه گیری ها
روشها
خطوط سلولی و پلاسمیدها
اثر جلوگیری از MEF-2 بر روی حالت Tax و تکثیر 1- HTLV
سطوح MEF-2 mRNA در نمونه های بالینی
سلولهای اصلی و عفونت
عیارگری ایمونوپریسیپیتاسیون با هم
میکروسکوپی هم کانون
اثرات جلوگیری MEF-2A بر روی بکارگیری عوامل استنساخی به LTR
عیارگری انتقال تحرک الکتروفورتیک (EMSA)
آرایه پروتئین /DNA برای توصیف MEF-2 یکی کننده ی مسیرهای سیگنال دهی روی عفونت 1- HTLV سلولهای CD4+ T
کلمات کلیدی :
Comparative studies between HTLV-1 and HTLV-2 function and ... https://books.google.com/books?isbn=2889194981 Umberto Bertazzoni, Françoise Bex - 2015 - Microbiology Human T cell leukemia virus type 1 and type 2 (HTLV-1 and -2) are two ... whereas HTLV-2 infection is not etiologically linked to human disease. ... Evidence showed that Tax-1 plays an essential role in mediating transformation of T lymphocytes ... is crucial in deciphering the molecular pathogenesis of HTLV-1-associated ... HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic ... - PLOS journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001274 by Y Satou - 2011 - Cited by 147 - Related articles Feb 10, 2011 - Therefore, HTLV-1 induces the proliferation of infected CD4+ T cells to increase further ... These results indicate that HBZ plays a critical role in neoplastic and ... of CD4+ T cells and predisposes expressing cells to transform in due course. .... CD4+Foxp3+ T cells of HBZ-Tg mice expressed Treg-associated ... Constitutive expression of IRF-5 in HTLV-1-infected T cells https://www.spandidos-publications.com/ijo/47/1/361/download by C Ishikawa - 2015 - Cited by 1 - Related articles IRF-5 was also upregulated in HTLV-1-infected T-cell lines at protein level. ... indicated that IRF-5 plays essential roles in the regulation of genes involved in the ... HBZ, a new important player in the mystery of adult T-cell leukemia www.bloodjournal.org/content/108/13/3979.full.pdf by JM Mesnard - 2006 - Cited by 96 - Related articles Dec 15, 2006 - role in T-cell transformation) in more than. 50% of ATL cells. ... of cellular dysfunction associated to Tax expression and aberrant regulation of cyclin, ... theoretical model, whereby Tax plays a central role in ATL induction. However ... nonmalignant T cells randomly infected with HTLV-1. Yet, efforts made to ... Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and ... - MDPI www.mdpi.com/1999-4915/7/12/2952/pdf by JM Mesnard - 2015 - Cited by 9 - Related articles Dec 9, 2015 - Thirty years ago, human T-cell leukemia virus type 1 (HTLV-1) was the first human ... HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ... There is nonetheless evidence that cellular receptors play an important role in .... Multifaceted Processes in the Transformation of Infected Cells.