عنوان فارسی مقاله: | تنظیم رو به پایین pu.1 در لوسمی حاد میلوئیدی (مغز استخوان) (AML) القا شده از اشعه در موش: از مکانیسم ملکولی تا AML انسانی |
| عنوان انگلیسی مقاله: |
PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML |
چکیده
مقدمه
مدلسازی rAml موش
اختلالات سیتوژنیکی پس از آنکه در معرض اشعه x قرار گرفتند
جهش 5 نقطه اکنون sfpil 5
سلول‌های هدف برای توسعة rAml
pU1 و سرنوشت سلول هماتوپوئتیک
تنظیم ژن بوسیلة pu.1
Pu.l و لوسمی میلوئیدی
رابطه بین rAml موش و Aml (t) انسان
نتیجه‌گیری و جهت‌یابی‌های آینده
کلمات کلیدی :
cute Myelogenous Leukemia - Page 34 - Google Books Resulthttps://books.google.com/books?isbn=1597453226Judith E. Karp - 2009 - MedicalIncreased PU.1 levels favor myeloid over lymphoid and monocyte over ... Second, radiation-induced murine AML is often associated with deletion of one PU. ... Downregulation of the bcl-2 promoter via an EICE and GAS element may account ...Genome-scale definition of the transcriptional programme associated ...search.proquest.com/openview/28146ba775ecccd127a103d4ae16b2a2/1?pq...cbl...by JI Sive - 2016 - Cited by 2 - Related articles... factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced AML, and PU.1 downregulation and/or ...Full-Text XML - MDPI.comwww.mdpi.com/1422-0067/17/11/1850/xmlIntroduction Murine models are indispensable in studying radiation-induced acute myeloid .... S. Nutt S.L. Badie C. PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): From molecular mechanism to human AML ...Runx1 - runt related transcription factor 1www.ihop-net.org/UniPub/iHOP/bng/119865.htmlWe show a converse role for AKT/FOXOs in acute myeloid leukemia ( AML). ... Our results suggest that murine radiation-induced AML stem cells arise from ... Indeed, downregulation of either Runx1 or CBFbeta protein level accelerates cell .... the tumor suppressor gene PU.1 thereby contributing to the development of AML.